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Precision Editing of Large Animal Genomes

作者:hsj003 | 时间:2022-5-30 03:41:20 | 阅读:626| 显示全部楼层

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The multiple applications of genetically modi fi ed large animals. The pig is shown as an example. The fi rst application is to improve traits in the farm animal. Examples of the potential improved traits include (1) resistance to diseases, (2) improved nutrition such as introducing a gene to produce the healthier omega-3 fatty acids to replace the normal omega-6 fatty acids (Lai et al., 2006), and (3) reducing the environmental impact of major pig production facilities by reducing phosphorous in manure (Golovan et al., 2001). The second application of genetically modi fi ed pigs is for biomedical products such as organ transplantation ( 20071210031618/ or speci fi c functional organ parts such as heart valves and subcellular structures. Examples include inactivating genes such as a -1,3-galactose that produce powerful immune responses when introduced into humans and eliminating the potential spread of porcine endogenous retroviruses. The third application of genetically modi fi ed pigs is the creation of animals that closely mimic human diseases such as cystic fi brosis (Rogers et al., 2008), cardiovascular disease, and cancer. For color version of this fi gure, the reader is referred to the online version of this book.




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